It is located along the South Carolina - North Carolina border in northern Pickens County, South Carolina nearest to the town of Rosman, North Carolina. From I-85 Exit 21 in South Carolina, one can reach Sassafras Mountain by driving north on US-178 until reaching the unincorporated community of Rocky Bottom. From there, take F. Van Clayton Highway (a local road) about 4.7 miles (7.6 km) to the parking lot at the top. From Rosman, follow US-178 south. The summit is an easy 300 foot walk from the parking lot and is, by merit of not having stairs, handicapped accessible, although the path is fairly steep.